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<br /> <meta charset="utf-8" /> <p dir="ltr"><b id="docs-internal-guid-dce7bc53-7fff-9f7f-29ef-41c6ac0e55d6">170 또 다른 연구에서 Lu 등은 갈락토스(Gal)를 리간드로 사용하여 HCC 세포에 과발현된 아시아로글리코프로테인 수용체(ASGPR)를 표적화했습니다. 171 이들은 세포내이입을 촉진하고 약물 전달 효율을 크게 향상시키는 Gal 변형 셀라스트롤 나노입자(CE-Gal-NPs)를 개발했습니다. 이 나노입자는 전신 독성을 줄이면서 ROS 매개 페로프토시스를 유도합니다. 또한, Tang 등은 효율적인 뇌종양 표적화를 달성하는 아포리포단백질 E(ApoE) 펩타이드 변형 TBTP(트리페닐아민 벤조비스[티아디아졸] 티오펜 피리디늄)-금 나노입자(ApoE-TBTP-Au NPs)를 개발했습니다. 172 ApoE 펩타이드는 BBB 수용체에 특이적으로 결합하여 정확한 전달을 보장하는 동시에 NIR-II 이미징을 통해 실시간으로 과정을 모니터링할 수 있도록 합니다. 더욱이, 금 기반 NIR-II 활성제는 티오레독신 환원효소(TrxR) 과발현에 반응하여 ROS를 방출함으로써 교종 세포에서 페로프토시스 경로를 활성화하고, 선택적으로 HMOX1 매개 페로프토시스를 유발합니다. 이 표적 전략은 GBM 성장을 효과적으로 억제하고 교종을 가진 쥐의 생존 시간을 연장시켜 TBTP-Au가 뇌종양 치료를 위한 유망한 치료 플랫폼으로서의 잠재력을 가지고 있음을 보여줍니다.</b></p> <a class="seoquake-nofollow" href="https://esports-green.isweb.co.kr/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"><span 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