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물리화학적 특성 최적화 나노의약품의 물리화학적 특성을 최적화하는 것은 특정 종양 침투 능력을 부여하는 강력한 전략입니다. 예를 들어, Shen 등은 ROS 폭풍을 유도하고 효율적인 페로프토시스 치료를 달성하기 위해 전하 전환 나노 플랫폼(PEG-PAH-DMMA 및 Gd 3+ 로 코팅된 HMON에 탑재된 타목시펜 [TAF-HMON-CuP@PPDG])을 설계했습니다. 179 이 플랫폼은 종양 미세환경(TME)의 약산성 조건을 이용하여 전하 전환을 유발함으로써 종양 침투 및 세포 내 흡수를 크게 향상시켰습니다. 종양 세포 내에서 방출된 타목시펜(TAF)은 미토콘드리아 복합체 I 억제제로 작용하여 해당 과정과 세포 내 산성화를 촉진하고 CuP를 Cu 2+ 와 H 2 O 2 로 분해하는 반응을 촉매합니다 . 이후, Cu 2+는 펜톤 유사 반응에 참여하여 ROS와 Cu⁺를 생성하고, 이는 촉매 순환 과정에서 H 2 O 2 와 반응하여 더 많은 ROS를 생성하고 Cu 2+를 재생성합니다 <a href="https://blacktv99.clickn.co.kr/" target="_blank" style="font-size:0;line-height:0;text-decoration:none;" rel="nofollow noreferrer noopener" class="seoquake-nofollow"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">블랙티비</span></a> <a href="https://blacktv88.clickn.co.kr/" target="_blank" style="font-size:0;line-height:0;text-decoration:none;" rel="nofollow noreferrer noopener" class="seoquake-nofollow"> <span 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