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USP8에 의한 탈유비퀴틴화는 이 과정을 미세하게 조절합니다. 이 경로는 유비퀴틴 의존적인 CIE 매개 수용체 내재화를 이용하여 질병 관련 단백질을 제거하는 방법을 보여줍니다. 또한, 응집 의존성 내포작용(ADE)은 클라트린 또는 다이나민 매개 경로와 형태학적 및 기계적으로 구별되는 액틴 구동 거대 내포작용 경로입니다. 149 ADE는 세포외 도메인 응집을 촉진하는 물리적 또는 화학적 자극에 의해 유도되며, 응집된 단백질과 이 경로를 통해 재분류된 기존 클라트린 의존성 운반체의 리소좀 분해를 촉진합니다. 이러한 적응성은 LYTAC 매개 단백질 분해를 위한 전달 경로로서 ADE의 치료 잠재력을 강조합니다. VAMP2, VAMP3, VAMP8을 포함한 소포 관련 막 단백질(VAMP)은 세포막 함입 부위에 풍부하게 존재하며, 시가 독소와 같은 세균 독소의 클라트린 비의존적 세포내이입(CIE) 과정에서 초기 흡수 과정에 관여합니다.<sup> 150</sup> 이러한 발견은 수용체 수송 및 화물 경로 설정에서 CIE의 활용을 더욱 뒷받침합니다. <a class="seoquake-nofollow" href="https://zzgtv.com" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">짱구스포츠</span></a> <a class="seoquake-nofollow" href="https://totogal.net/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">토토갤</span></a> <a class="seoquake-nofollow" href="https://blacktv99.clickn.co.kr/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span 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