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왜냐하면 MB37-cIAP1 RING F616A 는 여전히 MLKL에 결합하여 사멸 활성을 억제하기 때문이다( 그림 4A ). 이와 일관되게, MLKL과 cIAP1을 분해하는 Smac-MB37 발현 또한 HT29 세포의 TNF 유도 세포 사멸에 대한 민감도를 증가시키지 못했습니다( 그림 4A ). 더욱이, 독시사이클린 단독 처리는 MB37-cIAP1 RING 및 MB32-cIAP1 RING 발현 세포의 클론 형성 생존율을 감소시킨 반면, MB37-cIAP1 RING F616A , MB32-cIAP1 RING F616A 및 Smac-MB37 발현의 영향은 미미했으며 대조군인 MB32 및 MB37과 유사했습니다( 그림 4C 및 4D). 이 데이터는 MB32- 및 MB37-cIAP1 RING이 고유한 E3 리가아제 활성을 통해 다른 단백질을 분해하여 암세포의 장기적인 클론 형성 성장을 억제하고 세포를 TNF에 민감하게 만들어야 함을 시사합니다. MB37-cIAP1 RING 발현은 BAF 단백질 복합체의 분해를 유발합니다. MB37-cIAP1 RING이 암세포의 클론 형성 생존을 감소시키는 대체 표적을 가지고 있는지 알아보기 위해 질량 분석법을 이용하여 전체 단백질 발현량을 정량화했습니다. 놀랍게도, MLKL 외에도 MB37-cIAP1 RING 발현은 RNA 및 유전자 전사 조절과 관련된 단백질들의 발현량을 감소시켰습니다( 그림 5A , 5B 및 데이터 S1 ). 이러한 효과는 MB37 또는 MB37-cIAP1 RING F616A 를 발현하는 세포에서는 관찰되지 않았습니다( 그림 5A , 5B 및 데이터 S1 ). 이는 이러한 단백질들이 내인성 IAP 활성화가 아닌, MB37-cIAP1 RING의 E3 리가제 활성을 통해 직간접적으로 표적화됨을 시사합니다. 표적을 시각적으로 이해하기 위해 단백질-단백질 상호작용(PPI) 네트워크 분석을 수행했습니다. <a class="seoquake-nofollow" href="https://zzgtv.com" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">짱구스포츠</span></a> <a class="seoquake-nofollow" href="https://totogal.net/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span 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