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<br /> <meta charset="utf-8" /> <p dir="ltr"><b id="docs-internal-guid-cb1cc765-7fff-f961-f04c-1716e239f190">특히, CAF는 CD8 + T 세포 와 상호작용하는 주요 세포 유형 중 하나였으며 , 특히 CAF가 풍부한 두 개의 염증성 veHCC에서 이러한 경향이 두드러졌습니다( 그림 5D ~5F). 일관되게, CD8 + T 세포는 CAF와 공간적으로 인접해 있었습니다( 그림 5M 및 5N). CAF와 CD8 + T 세포가 풍부한 영역에서는 근섬유모세포성 CAF(myoCAF)와 TGF-β 신호가 강하게 활성화되었습니다( 그림 5O ~5R). 이러한 결과는 대량 RNA-seq 결과와 일치하며 TGF-β 매개 면역억제의 역할을 뒷받침합니다. T 세포 억제에 TAM이 관여한다는 기존 연구 결과( 49 , 50) 를 고려하여 , 우리는 염증성 veHCC에서 TAM을 구체적으로 분석했습니다. CD8 + T 세포와 대식세포 간의 상호작용이 관찰되었으며 ( 그림 5D ~5F), 이는 염증이 발생한 veHCC에서 침윤성 종양 관련 대식세포(TAM)가 유의하게 증가했음을 보여주는 멀티플렉스 염색 데이터와 일치합니다( 그림 4S ). 또한, 염증이 발생한 veHCC는 IL6, TNF-α, 상피-간엽 전환(EMT) 및 KRAS 경로의 활성화를 나타냈으며( 그림 S7H ~S7K), 이는 대량 RNA 시퀀싱 분석에서 나타난 종양 발생 경로의 풍부함을 더욱 뒷받침합니다( 그림 S6N ). 이러한 데이터들을 종합해 볼 때, 염증이 발생한 veHCC는 염증 신호를 활성화하는 동시에 면역 억제 미세 환경을 조성하는 것으로 보입니다.</b></p> <a class="seoquake-nofollow" href="https://www.actionz.org/주소콘" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"><span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">주소콘</span></a> <a class="seoquake-nofollow" href="https://www.actionz.org/링크모음" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">링크모음</span></a> <a class="seoquake-nofollow" 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